| Regulating Pair |
| Introduced Variation |
Glutamine addition (24 hours) |
Metabo Info
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| Induced Change |
HPRT1 protein expression levels: decrease |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of HPRT1 protein abundances after glutamine addition through 2-D quant kit analysis or MALDI-TOF MS analysis. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
HCT-8 cells (Human colon tumor cells) |
Intestinal epithelium |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that glutamine addition causes the decrease of HPRT1 protein expression compared with control group in the HCT-8 cells under apoptotic conditions. |
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| References |
| 1 |
Glutamine regulates the human epithelial intestinal HCT-8 cell proteome under apoptotic conditions. Mol Cell Proteomics. 2007 Oct;6(10):1671-9.
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