| Regulating Pair |
| Introduced Variation |
Knockout of Mgat5 |
Protein Info
|
| Induced Change |
N-Acetylneuraminic acid concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of N-acetylneuraminic acid concentration after Mgat5 knockout through LC-MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Liver |
| Subcellular Location |
Golgi apparatus (Golgi apparatus membrane); Cytoplasm (Perikaryon); Secreted |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
|
| Details |
It is reported that knockout of Mgat5 leads to the decrease of N-acetylneuraminic acid levels compared with control group. |
|
|
|
|
|
|
|
| References |
| 1 |
N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway. J Biol Chem. 2014 Jun 6;289(23):15927-41.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
