| Regulating Pair |
| Introduced Variation |
Knockout of Cpt1c |
Protein Info
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| Induced Change |
Pyroglutamic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of pyroglutamic acid concentration after Cpt1c knockout through liquid chromatography/tandem mass spectrometry (HPLC/MS/MS2) and gas chromatography/mass spectrometry (GC/MS) based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Brain |
| Subcellular Location |
Mitochondrion (Mitochondrion outer membrane); Cell junction (Synapse); Cell projection (Axon; Dendrite); Endoplasmic reticulum |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Cpt1c leads to the decrease of pyroglutamic acid levels compared with control group. |
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| References |
| 1 |
Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 2012 Oct 25;13:23.
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