| Regulating Pair |
| Introduced Variation |
Knockout of Pla2g3 |
Protein Info
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| Induced Change |
Eicosapentaenoic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of eicosapentaenoic acid concentration after Pla2g3 knockout through ESI-MS based metabolomics. |
| Disease Status |
Colorectal cancer |
ICD-11: 2B91 |
| Organ/Tissue/Cell Line |
N.A. |
Colon |
| Subcellular Location |
Secreted; Membrane (Cell membrane); Cytoplasm (Cytoskeleton); Centrosome (Centriole; Recycling endosome) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Pla2g3 leads to the increase of eicosapentaenoic acid levels compared with control group. |
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| References |
| 1 |
Group III phospholipase A 2 promotes colitis and colorectal cancer. Sci Rep. 2017 Sep 25;7(1):12261.
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