| Regulating Pair |
| Introduced Variation |
Knockout of Fh |
Protein Info
|
| Induced Change |
Argininosuccinic acid concentration: increase |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of argininosuccinic acid concentration after Fh knockout through liquid chromatography - electrospray ionization - mass spectrometry (LCMS) based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Kidney |
| Subcellular Location |
Mitochondrion; Cytoplasm (Cytosol); Nucleus (Chromosome) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
|
| Details |
It is reported that knockout of Fh leads to the increase of argininosuccinic acid levels compared with control group. |
|
|
|
|
|
|
|
| References |
| 1 |
Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells. Cancer Metab. 2013 Mar 21;1(1):12.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
