| Regulating Pair |
| Introduced Variation |
Knockout of Gde1 |
Protein Info
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| Induced Change |
Serine concentration: decrease (FC= 1.6) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-serine concentration after Gde1 knockout through reverse-phase chromatography and LC-MS based metabolomics. |
| Disease Status |
Healthy individual |
| Subcellular Location |
Membrane (Cell membrane); Cytoplasm (Cytoplasmic Vesicle membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Gde1 leads to the decrease of serine levels compared with control group. |
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| References |
| 1 |
The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chem Biol. 2010 Aug 27;17(8):831-40.
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