| Regulating Pair |
| Introduced Variation |
Knockout of Grm2 |
Protein Info
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| Induced Change |
3,4-Dihydroxybenzeneacetic acid concentration: decrease (FC = 0.72) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 3,4-dihydroxybenzeneacetic acid concentration after mGlu2/3 knockout through HPLC based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Striatum |
| Subcellular Location |
Membrane (Cell membrane); Cell junction (Synapse; Dendrite) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of mGlu2/3 leads to the decrease of 3,4-dihydroxybenzeneacetic acid levels compared with control group. |
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| References |
| 1 |
Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice. BMC Neurosci. 2013 Sep 22;14:102.
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