| Regulating Pair |
| Introduced Variation |
Overexpression of Npy |
Protein Info
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| Induced Change |
Homovanillic acid concentration: increase (FC = 3.00) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of homovanillic acid concentration after Npy overexpression through HPLC based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Hypothalamus |
| Subcellular Location |
Secreted; Cytoplasm (Cytoplasmic vesicle; Secretory vesicle; Neuronal dense core vesicle) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that overexpression of Npy leads to the increase of homovanillic acid levels compared with control group. |
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| References |
| 1 |
Effects of neuropeptide Y (NPY) and [D-Trp32]NPY on monoamine and metabolite levels in dialysates from rat hypothalamus during feeding behavior. Neuropeptides. 1996 Aug;30(4):391-8.
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