| Regulating Pair |
| Introduced Variation |
Knockout of Ptpmt1 |
Protein Info
|
| Induced Change |
3-Hydroxybutyric acid concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 3-hydroxybutyric acid concentration after Ptpmt1 knockout through kit detection. |
| Disease Status |
Fatty liver disease |
ICD-11: DB92 |
| Organ/Tissue/Cell Line |
N.A. |
Serum |
| Subcellular Location |
Mitochondrion (Mitochondrion inner membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
|
| Details |
It is reported that knockout of Ptpmt1 leads to the decrease of 3-hydroxybutyric acid levels compared with control group. |
|
|
|
|
|
|
|
| References |
| 1 |
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. Mol Cell Biol. 2012 Jul;32(14):2685-97.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
