| Regulating Pair |
| Introduced Variation |
Overexpression of Pla2g10 |
Protein Info
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| Induced Change |
7-HDoHE concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 7-HDoHE concentration after Pla2g10 overexpression through ESI-MS based metabolomics. |
| Disease Status |
Inflammatory bowel disease |
ICD-11: DD72 |
| Organ/Tissue/Cell Line |
N.A. |
Spleen |
| Subcellular Location |
Secreted; Lysosome; Cytoplasm (Cytoplasmic vesicle; Secretory vesicle; Acrosome) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that overexpression of Pla2g10 leads to the increase of 7-HDoHE levels compared with control group. |
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| References |
| 1 |
Group X Secreted Phospholipase A2 Releases 3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016 Mar 25;291(13):6895-911.
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