| Regulating Pair |
| Introduced Variation |
Knockout of Acer1 |
Protein Info
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| Induced Change |
Sphinganine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of sphinganine concentration after Acer1 knockout through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Skin |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Acer1 leads to the increase of sphinganine levels compared with control group. |
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| References |
| 1 |
Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 Nov 14;9(5):1488-1500.
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