| Regulating Pair |
| Introduced Variation |
Knockout of Slc23a1 |
Protein Info
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| Induced Change |
6-Bromo-6-deoxy-L-ascorbate concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 6-bromo-6-deoxy-L-ascorbate concentration after Slc23a1 knockout through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Liver |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Slc23a1 leads to the decrease of 6-bromo-6-deoxy-L-ascorbate levels compared with control group. |
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| References |
| 1 |
Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest. 2010 Apr;120(4):1069-83.
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