| Regulating Pair |
| Introduced Variation |
Antagonist (GRA1) of GCGR |
Protein Info
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| Induced Change |
Histidine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-histidine concentration after GCGR antagonist through kit detection. |
| Disease Status |
Hyperglycemic hyperosmolar syndrome |
ICD-11: 5A20 |
| Organ/Tissue/Cell Line |
N.A. |
Plasma |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that antagonist of GCGR leads to the increase of histidine levels compared with control group. |
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| References |
| 1 |
Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist. PLoS One. 2012;7(11):e49572.
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