| Regulating Pair |
| Introduced Variation |
Knockout of Fxn |
Protein Info
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| Induced Change |
Heme concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of heme concentration after Fxn knockout through kit detection. |
| Disease Status |
Healthy individual |
| Subcellular Location |
Cytoplasm (Cytosol); Mitochondrion |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Fxn leads to the decrease of heme levels compared with control group. |
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| References |
| 1 |
Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet. 2005 Dec 15;14(24):3787-99.
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