| Regulating Pair |
| Introduced Variation |
Knockout of Sugct |
Protein Info
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| Induced Change |
Glutaric acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glutaric acid concentration after Sugct knockout through LCMS based metabolomics. |
| Disease Status |
Diabetes mellitus |
ICD-11: 5A14 |
| Organ/Tissue/Cell Line |
N.A. |
Kidney |
| Subcellular Location |
Mitochondrion |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Sugct leads to the increase of glutaric acid levels compared with control group. |
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| References |
| 1 |
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Cell Mol Life Sci. 2020 Sep;77(17):3423-3439.
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