| Regulating Pair |
| Introduced Variation |
Knockout of Ldhc |
Protein Info
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| Induced Change |
Oxoglutaric acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of oxoglutaric acid concentration after Ldhc knockout through CE-TOFMS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Testis |
| Subcellular Location |
Cytoplasm |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Ldhc leads to the increase of oxoglutaric acid levels compared with control group. |
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| References |
| 1 |
Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A. J Biochem. 2019 Apr 1;165(4):323-334.
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