| Regulating Pair |
| Introduced Variation |
Knockout of IL10 |
Protein Info
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| Induced Change |
2-Hydroxyglutarate concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxyadipic acid concentration after Il10 knockout through GCMS based metabolomics. |
| Disease Status |
Crohn disease |
ICD-11: DD70 |
| Organ/Tissue/Cell Line |
N.A. |
Urine |
| Subcellular Location |
Secreted |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Il10 leads to the decrease of 2-hydroxyglutarate levels compared with control group. |
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| References |
| 1 |
Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease. J Proteome Res. 2009 Apr;8(4):2045-57.
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