| Regulating Pair |
| Introduced Variation |
Knockout of Dlst |
Protein Info
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| Induced Change |
Aspartic acid concentration: decrease (FC = 0.71) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-aspartic acid concentration after Dlst knockout through HPLC based metabolomics. |
| Disease Status |
Alzheimer disease |
ICD-11: 8A20 |
| Organ/Tissue/Cell Line |
N.A. |
Cerebral cortex |
| Subcellular Location |
Mitochondrion (Mitochondrion matrix); Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Dlst leads to the decrease of aspartic acid levels compared with control group. |
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| References |
| 1 |
Brain [U-13 C]glucose metabolism in mice with decreased -ketoglutarate dehydrogenase complex activity. J Neurosci Res. 2011 Dec;89(12):1997-2007.
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