| Regulating Pair |
| Introduced Variation |
Knockout of Pla2g3 |
Protein Info
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| Induced Change |
12-HETE concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 12-HETE concentration after Pla2g3 knockout through LC-ESI-MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Epididymis |
| N.A. |
Testis |
| Subcellular Location |
Secreted; Membrane (Cell membrane); Cytoplasm (Cytoskeleton); Centrosome (Centriole; Recycling endosome) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Pla2g3 leads to the decrease of 12-HETE levels compared with control group. |
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| References |
| 1 |
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J Clin Invest. 2010 May;120(5):1400-14.
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