Details of Experiment

Regulating Pair
Introduced Variation	Inhibition (JZL184) of Mgll	Protein Info
Induced Change	MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) concentration: increase (FC = 4)	Metabo Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the change of MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) concentration after Mgll inhibition through HPLC-MS (LTQ Orbitrap MS coupled to an Accela HPLC system) based metabolomics.
Disease Status	Healthy individual
Organ/Tissue/Cell Line	B16 cells (Mouse melanoma cells)	Skin
Subcellular Location	Cytoplasm (Cytosol); Membrane
Tested Species	Species: Mus musculus (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Rodentia Family: Muridae Genus: Mus Species: Mus musculus
Details	It is reported that inhibition of Mgll leads to the increase of MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) levels compared with control group in B16 cells.

References
1	Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17558-63.

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