| Regulating Pair |
| Introduced Variation |
Inhibition (L-trans-pyrrolidine-2,4-dicar-boxylic acid (PDC)) of SLC1A1 |
Protein Info
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| Induced Change |
Glutamic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-glutamic acid concentration after SLC1A1 inhibition through 3H- or 14C-labeled amino acids assay. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS cells (African Green Monkey Kidney Fibroblast cells) |
N.A. |
| Subcellular Location |
Membrane (Cell membrane; Apical cell membrane); Cell junction (Synaptosome); Endosome (Early endosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of SLC1A1 leads to the decrease of glutamic acid levels compared with control group in COS cells. |
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| References |
| 1 |
Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci. 1994 Sep;14(9):5559-69.
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