| Regulating Pair |
| Introduced Variation |
Overexpression of SLC36A1 |
Protein Info
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| Induced Change |
5-Aminolevulinic acid concentration: increase (FC = 3) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 5-aminolevulinic acid concentration after SLC36A1 overexpression through 14C-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS-7 cells (Transformed african green monkey kidney fibroblast cells) |
N.A. |
| Subcellular Location |
Membrane (Cell membrane); Lysosome (Lysosome membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLC36A1 leads to the increase of 5-aminolevulinic acid levels compared with control group in COS-7 cells. |
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| References |
| 1 |
Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). Br J Pharmacol. 2010 Mar;159(6):1339-53.
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