Details of Metabolite

General Information of MET (ID: META00378)
Name 5-Aminolevulinic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5 Aminolaevulinate; 5 Aminolevulinate; 5-ALA; 5-Amino-4-oxo-pentanoate; 5-Amino-4-oxo-pentanoic acid; 5-Amino-4-oxopentanoate; 5-Amino-4-oxopentanoic acid; 5-Amino-4-oxovalerate; 5-Amino-4-oxovaleric acid; 5-Amino-levulinate; 5-Amino-levulinic acid; 5-Aminolaevulinate; 5-Aminolaevulinic acid; 5-Aminolevulinate; Acid hydrochloride, aminolevulinic; Acid, Delta-aminolevulinic; Acid, aminolevulinic; Aladerm; Amino-levulinic acid; Aminolevulinic acid; Aminolevulinic acid hydrochloride; Bertek brand OF aminolevulinic acid hydrochloride; DALA; Delta Aminolevulinic acid; Hydrochloride, aminolevulinic acid; Kerastick; Levulan; delta-ALA; delta-Aminolevulinic acid
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Fatty acyls;Food;Drug;Toxins/Pollutant;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
137
HMDB ID
HMDB0001149
Formula
C5H9NO3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00430
DrugBank ID
DB00855
ChEBI ID
17549
FooDB ID
FDB022452
ChemSpider ID
134
METLIN ID
6037
Physicochemical Properties Molecular Weight 131.13 Topological Polar Surface Area 80.4
XlogP -3.8 Complexity 121
Heavy Atom Count 9 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
5-Aminolevulinic acid is an intermediate in heme synthesis. This is the first compound in the porphyrin synthesis pathway. It is produced by the enzyme ALA synthase, from glycine and succinyl CoA. This reaction is known as the Shemin pathway. Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Amino acid/auxin permease (AAAP)
            Solute carrier family 36 member 1 (SLC36A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC36A1
                      Induced Change 5-Aminolevulinic acid concentration: increase (FC = 3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC36A1 leads to the increase of 5-aminolevulinic acid levels compared with control group.
References
1 Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). Br J Pharmacol. 2010 Mar;159(6):1339-53.

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