| Regulating Pair |
| Introduced Variation |
Mutation (N484A) of SLC1A4 |
Protein Info
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| Induced Change |
Succinic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of succinic acid concentration after SLC1A4 mutation (N484A) through 3H- or 14C-labeled amino acids assay. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
COS-7 cells (Transformed African Green Monkey Kidney Fibroblast cells) |
Kidney |
| Subcellular Location |
Membrane; Melanosome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (N484A) of SLC1A4 leads to the decrease of succinic acid levels compared with control group in COS-7 cells. |
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| References |
| 1 |
Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3. J Biol Chem. 2014 Jun 13;289(24):16998-7008.
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