| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of Gapdh |
Protein Info
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| Induced Change |
Glutathione concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glutathione concentration after Gapdh knockdown through [3H]labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Cumulus-denuded oocytes |
Ovarian |
| Subcellular Location |
Cytoplasm (Cytosol; Cytoskeleton); Nucleus; |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockdown of Gapdh leads to the decrease of glutathione levels compared with control group in Cumulus-denuded oocytes. |
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| References |
| 1 |
Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference. J Cell Physiol. 2018 Sep;233(9):6952-6964.
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