| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of SLC25A22 |
Protein Info
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| Induced Change |
Asparagine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-asparagine concentration after SLC25A22 knockdown through LC-MS based metabolomics. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
DLD1 cells (Human colon carcinoma cells) |
Colon |
| Subcellular Location |
Mitochondrion (Mitochondrion inner membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of SLC25A22 leads to the decrease of asparagine levels compared with control group in DLD1 cells. |
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| References |
| 1 |
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. Gastroenterology. 2016 Nov;151(5):945-960.e6.
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