| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of Pkm |
Protein Info
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| Induced Change |
Lactic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-lactic acid concentration after Pkm knockdown through LC-MS based metabolomics. |
| Disease Status |
Lung cancer |
ICD-11: 2C25 |
| Organ/Tissue/Cell Line |
H1299 cells (Human lung cancer cells) |
Lung |
| Subcellular Location |
Cytoplasm; Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockdown of Pkm leads to the increase of lactic acid levels compared with control group in H1299 cells. |
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| References |
| 1 |
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008 Mar 13;452(7184):230-3.
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