| Regulating Pair |
| Introduced Variation |
Overexpression of Alox15b |
Protein Info
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| Induced Change |
15-HETE concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 15-HETE concentration after Alox15b overexpression through LC-MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Cytoplasm (Cytosol; cytoskeleton); Membrane (Cell membrane); Cell junction (Adherens junction; Focal adhesion); Nucleus |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that overexpression of Alox15b leads to the increase of 15-HETE levels compared with control group in HEK293 cells. |
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| References |
| 1 |
Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. FASEB J. 2013 May;27(5):1939-49.
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