| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of GGT1 |
Protein Info
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| Induced Change |
Argininosuccinic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of argininosuccinic acid concentration after GGT1 knockdown through LC-MS based metabolomics. |
| Disease Status |
Renal cell carcinoma |
ICD-11: 2C90 |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of GGT1 leads to the increase of argininosuccinic acid levels compared with control group in HEK293 cells. |
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| References |
| 1 |
Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
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