| Regulating Pair |
| Introduced Variation |
Overexpression of SLC7A2 |
Protein Info
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| Induced Change |
Homo-L-arginine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of homo-L-arginine concentration after SLC7A2 overexpression through kit detection. |
| Disease Status |
Coronary artery disease |
ICD-11: BA80 |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLC7A2 leads to the increase of homo-L-arginine levels compared with control group in HEK293 cells. |
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| References |
| 1 |
The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B. Sci Rep. 2017 Jul 6;7(1):4767.
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