| Regulating Pair |
| Introduced Variation |
Knockout of CMAS |
Protein Info
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| Induced Change |
N-Acetylneuraminic acid concentration: increase (FC = 30) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of N-acetylneuraminic acid concentration after CMAS knockout through RP-HPLC based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Mesc cells (embryonic stem cells) |
Ovary |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of CMAS leads to the increase of N-acetylneuraminic acid levels compared with control group in HEK293 cells and Mesc cells. |
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| References |
| 1 |
Sialylation Is Dispensable for Early Murine Embryonic Development in Vitro. Chembiochem. 2017 Jul 4;18(13):1305-1316.
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