| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of SLC25A23 |
Protein Info
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| Induced Change |
Calcium concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of calcium concentration after SLC25A23 knockdown through kit detection. |
| Disease Status |
Cervical Cancer |
ICD-11: 2C77 |
| Organ/Tissue/Cell Line |
HeLa cells (Human cervical cancer cells) |
Cervix |
| Subcellular Location |
Mitochondrion (Mitochondrion inner membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of SLC25A23 leads to the decrease of calcium levels compared with control group in HeLa cells. |
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| References |
| 1 |
SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol Biol Cell. 2014 Mar;25(6):936-47.
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