| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of MPST |
Protein Info
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| Induced Change |
Lactic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-lactic acid concentration after Mpst knockdown through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Human dermal fibroblasts |
Dermis |
| MSCs cells (Mesenchymal stem cells) |
Heart |
| Subcellular Location |
Cytoplasm; Mitochondrion; Cell junction (Synaptosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of Mpst leads to the increase of lactic acid levels compared with control group in human dermal fibroblasts and MSCs cells. |
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| References |
| 1 |
3-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation. Exp Cell Res. 2019 Dec 15;385(2):111683.
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