| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of ADA2 |
Protein Info
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| Induced Change |
Hypoxanthine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of hypoxanthine concentration after ADA2 knockdown through LC-MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HUVEC cells (Human umbilical vein endothelial cells) |
Umbilical vein endothelial |
| Subcellular Location |
Secreted |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of ADA2 leads to the increase of hypoxanthine levels compared with control group in HUVEC cells. |
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| References |
| 1 |
Cellular sensing of extracellular purine nucleosides triggers an innate IFN- response. Sci Adv. 2020 Jul 22;6(30):eaba3688.
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