| Regulating Pair |
| Introduced Variation |
Inhibition (WWL70) of Abhd6 |
Protein Info
|
| Induced Change |
Prostaglandin J2 concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of prostaglandin J2 concentration after Abhd6 inhibition through HPLC-MS (LTQ Orbitrap MS coupled to an Accela HPLC system) based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
J774 cells (Murine macrophage cells) |
N.A. |
| Subcellular Location |
Endosome (Late endosome membrane); Endosome (Lysosome membrane); Mitochondrion (Mitochondrion membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
|
| Details |
It is reported that inhibition of Abhd6 leads to the decrease of prostaglandin J2 levels compared with control group in J774 cells. |
|
|
|
|
|
|
|
| References |
| 1 |
Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17558-63.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
