| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of IDH3B |
Protein Info
|
| Induced Change |
Glucose concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of D-glucose concentration after IDH3B knockdown through liquid Chromatography-Mass Spectrometry based metabolomics. |
| Disease Status |
Oesophagus carcinoma |
ICD-11: 2E60 |
| Organ/Tissue/Cell Line |
KYSE30 cells (Esophageal squamous cell carcinoma cells) |
Esophagus |
| KYSE410 cells (Esophageal squamous cell carcinoma cells) |
Esophagus |
| Subcellular Location |
Mitochondrion |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that knockdown of IDH3B leads to the decrease of glucose levels compared with control group in KYSE30 cells and KYSE410 cells. |
|
|
|
|
|
|
|
| References |
| 1 |
APC/C-CDH1-Regulated IDH3 Coordinates with the Cell Cycle to Promote Cell Proliferation. Cancer Res. 2019 Jul 1;79(13):3281-3293.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
