| Regulating Pair |
| Introduced Variation |
Knockout of Sphk1 |
Protein Info
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| Induced Change |
Sphingosine 1-phosphate concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of sphingosine 1-phosphate concentration after Sphk1 knockout through LC-MS (liquid chromatographymassspectrometry) based metabolomics. |
| Disease Status |
Chronic kidney disease |
ICD-11: GB61 |
| Organ/Tissue/Cell Line |
Mature erythrocytes |
Plasma |
| Subcellular Location |
Cytoplasm; Endosome (Endosome membrane); Nucleus; Membrane (Cell membrane); Cell junction (Synapse) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Sphk1 leads to the decrease of sphingosine 1-phosphate levels compared with control group in Mature erythrocytes. |
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| References |
| 1 |
Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies. Circ Res. 2020 Jul 17;127(3):360-375.
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