| Regulating Pair |
| Introduced Variation |
Inhibition (Cysmethynil) of ICMT |
Protein Info
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| Induced Change |
Asparagine concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-asparagine concentration after ICMT inhibition through LC-MS/MS based metabolomics. |
| Disease Status |
Breast cancer |
ICD-11: 2C60 |
| Organ/Tissue/Cell Line |
MDA-MB-231 cells (Human breast cancer cells) |
Breast |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of ICMT leads to the decrease of asparagine levels compared with control group in MDA-MB-231 cells. |
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| References |
| 1 |
Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene. 2015 Jun;34(25):3296-304.
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