| Regulating Pair |
| Introduced Variation |
Inhibition (Chloromercuribenzenesulfonic acid (pCMBS)) of SLC16A1 |
Protein Info
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| Induced Change |
Lactic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after SLC16A1 inhibition through kit detection. |
| Disease Status |
Breast cancer |
ICD-11: 2C60 |
| Organ/Tissue/Cell Line |
MDA-MB-231 cells (Human breast cancer cells) |
Breast |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of SLC16A1 leads to the increase of lactic acid levels compared with control group in MDA-MB-231 cells. |
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| References |
| 1 |
Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. J Biol Chem. 2019 Dec 27;294(52):20135-20147.
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