| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment (1) for Validating Pair |
[1] |
| Method |
Quantifying the change of malic acid concentration after ICMT inhibition through gas chromatography/mass spectrometry based metabolomics. |
| Disease Status |
Breast cancer |
ICD-11: 2C60 |
| Organ/Tissue/Cell Line |
MDA-MB-231 cells (Human breast cancer cells) |
Breast |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of ICMT leads to the decrease of malic acid levels compared with control group in PC3 cells. |
| Details of Experiment (2) for Validating Pair |
[1] |
| Method |
Quantifying the change of malic acid concentration after ICMT inhibition through gas chromatography/mass spectrometry based metabolomics. |
| Disease Status |
Prostate cancer |
ICD-11: 2C82 |
| Organ/Tissue/Cell Line |
PC3 cells (Human prostatic cancer cells) |
Prostate |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Details |
It is reported that inhibition of ICMT leads to the decrease of malic acid levels compared with control group in PC3 cells. |
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Induced Change