| Regulating Pair |
| Introduced Variation |
Knockout of Sulf1 |
Protein Info
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| Induced Change |
Lactic acid concentration: increase (FC = 1.22) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after Sulf1 knockout through GC/MS based metabolomics. |
| Disease Status |
Ovarian cancer |
ICD-11: 2C73 |
| Organ/Tissue/Cell Line |
MEF cells (Mouse Embryonic Fibroblasts cells) |
Embryo |
| Subcellular Location |
Endoplasmic reticulum; Golgi apparatus (Golgi stack); Membrane (Cell surface) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Sulf1 leads to the increase of lactic acid levels compared with control group in MEF cells. |
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| References |
| 1 |
HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer. Oncotarget. 2015 Oct 20;6(32):33705-19.
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