| Regulating Pair |
| Introduced Variation |
Knockout of SLC1A4 |
Protein Info
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| Induced Change |
Serine concentration: decrease (FC = 0.10-0.20) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-serine concentration after SLC1A4 knockout through 3H-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Mouse Astrocytes |
Brain |
| Subcellular Location |
Membrane; Melanosome |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of SLC1A4 leads to the decrease of serine levels compared with control group in mouse Astrocytes. |
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| References |
| 1 |
ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9628-9633.
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