| Regulating Pair |
| Introduced Variation |
Knockout of Ppargc1a |
Protein Info
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| Induced Change |
Threonine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-threonine concentration after Ppargc1a knockout through Non-targeted LC-MS based metabolomics. |
| Disease Status |
Congestive heart failure |
ICD-11: BD10 |
| Organ/Tissue/Cell Line |
Mouse Cardiomyocytes |
Heart |
| Subcellular Location |
Nucleus (PML body) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Ppargc1a leads to the increase of threonine levels compared with control group in mouse Cardiomyocytes. |
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| References |
| 1 |
Heart specific PGC-1 deletion identifies metabolome of cardiac restricted metabolic heart failure. Cardiovasc Res. 2019 Jan 1;115(1):107-118.
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