| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of Slc27a5 |
Protein Info
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| Induced Change |
Cholic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cholic acid concentration after Slc27a5 knockdown through UPLC TOF-MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Mouse hepatocytes |
Liver |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane); Microsome; Membrane (Cell membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockdown of Slc27a5 leads to the decrease of cholic acid levels compared with control group in mouse hepatocytes. |
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| References |
| 1 |
Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy. J Proteome Res. 2011 Oct 7;10(10):4683-91.
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