| Regulating Pair |
| Introduced Variation |
Knockout of G6pc3 |
Protein Info
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| Induced Change |
Fructose 1,6-bisphosphate concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of fructose 1,6-bisphosphate concentration after G6pc3 knockout through LC-MS based metabolomics. |
| Disease Status |
Neutropenia |
ICD-11: 4B00 |
| Organ/Tissue/Cell Line |
Neutrophil precursor cells |
Bone marrow |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of G6pc3 leads to the decrease of fructose 1,6-bisphosphate levels compared with control group in neutrophil precursor cells. |
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| References |
| 1 |
Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1241-1250.
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