| Regulating Pair |
| Introduced Variation |
Overexpression of TKTL1 |
Protein Info
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| Induced Change |
Lactic acid concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-hydroxypropanoic acid concentration after TKTL1 overexpression through LC-MS/MS based metabolomics. |
| Disease Status |
Head and neck squamous cell carcinoma |
ICD-11: 2D60 |
| Organ/Tissue/Cell Line |
O11 cells |
N.A. |
| O28 cells |
N.A. |
| Subcellular Location |
Cytoplasm; Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of TKTL1 leads to the increase of lactic acid levels compared with control group in O11 cells and O28 cells. |
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| References |
| 1 |
TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 2010 Feb 1;16(3):857-66.
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