| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of Slc6a17 |
Protein Info
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| Induced Change |
Glycine concentration: decrease (FC = 0.30) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of glycine concentration after Slc6a17 knockdown through 3H-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
PC12 cells (Pheochromocytoma cells) |
Adrenal medulla |
| Subcellular Location |
Cytoplasm (Cytoplasmic vesicle; Secretory vesicle; Synaptic vesicle membrane); Cell junction (Synapse; Postsynapse) |
| Tested Species |
Species: Rattus norvegicus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Rattus
Species: Rattus norvegicus
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| Details |
It is reported that knockdown of Slc6a17 leads to the decrease of glycine levels compared with control group in PC12 cells. |
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| References |
| 1 |
The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine. Mol Pharmacol. 2008 Dec;74(6):1521-32.
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