| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of FABP4 |
Protein Info
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| Induced Change |
5-Hydroxymethylcytosine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 5-hydroxymethylcytosine concentration after FABP4 knockdown through DNA dot blot |
| Disease Status |
Ovarian cancer |
ICD-11: 2C73 |
| Organ/Tissue/Cell Line |
SKOV3ip1 cells (Mouse Ovarian carcinoma cells) |
Ovarian |
| Subcellular Location |
Cytoplasm; Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of FABP4 leads to the increase of 5-hydroxymethylcytosine levels compared with control group in SKOV3ip1 cells. |
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| References |
| 1 |
Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance. Cancer Res. 2020 Apr 15;80(8):1748-1761.
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