Details of Experiment

Regulating Pair
       Introduced Variation Inhibition (WWL70) of Abhd6 Protein Info
       Induced Change MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the change of MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) concentration after Abhd6 inhibition through HPLC-MS (LTQ Orbitrap MS coupled to an Accela HPLC system) based metabolomics.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line TGEM cells (Thioglycolate-elicited peritoneal macrophages cells) Peritoneum
BV2 cells (Murine microglial cells) Brain
       Subcellular Location Endosome (Late endosome membrane); Endosome (Lysosome membrane); Mitochondrion (Mitochondrion membrane)
       Tested Species   Species: Mus musculus  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
       Details It is reported that inhibition of Abhd6 leads to the increase of MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0) levels compared with control group in TGEM cells and BV2 cells.
References
1 Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17558-63.

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