| Regulating Pair |
| Introduced Variation |
Overexpression of EHMT2 |
Protein Info
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| Induced Change |
Serine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-serine concentration after EHMT2 overexpression through GC/MS based metabolomics. |
| Disease Status |
Bone metastasis |
ICD-11: 2E03 |
| Organ/Tissue/Cell Line |
U2OS cells (Human osteosarcoma cells) |
Bone |
| Subcellular Location |
Nucleus (Chromosome) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of EHMT2 leads to the increase of serine levels compared with control group in U2OS cells. |
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| References |
| 1 |
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 2013 Dec 3;18(6):896-907.
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